Notre Dame Integrated Imaging Facility

Past Award Winners - Best Imaging Publications 2013 and 2014

Award Winners - NDIIF Best Imaging Publications Calendar Year 2013

The Best Electron Microscopy Imaging Publication 2013 is awarded to Dr. Khachatur V. Manukyan, a post-doctoral research associate in the Department of Chemical and Biomolecular Engineering. Dr. Manukyan and coworkers published a series of three related publications describing studies of the combustion synthesis of novel nanostructured materials with tailored properties. The mechanisms of structural transformations, which occur in the combustion wave, were studied at micro-, nano-, and atomic levels. A unique combination of combustion diagnostics and SEM, FESEM, SEM/FIB, TEM techniques revealed microstructure-reactivity relationships for a variety of rapid heterogeneous reactions. The discoveries open new avenues for the synthesis of ultra-low dimensional solids. The three studies were published in: Carbon, 2013, 62, 302; doi: 10.1016/j.carbon.2013.06.014, J. Applied Physics, 2013, 113, 024302, doi: 10.1063/1.4773475, J. Materials Research, 2013, 28, 2611, doi: 10.1557/jmr.2013.234.     

 

The Best Biological Imaging Publication 2013 is awarded to Dr. Giles E. Duffield, Associate Professor in the Department of Biological Sciences. Dr. Duffield and coworkers have pioneered the use of Positron Emission Tomography (PET) to monitor the daily rhythms of small living animals. The researchers use 18-F-fluorodeoxyglucose (FDG), a radiolabeled sugar that is a PET marker for tissue metabolism levels. The authors investigated the effect of ID2 gene ablation on FDG biodistribution in mice. The PET imaging results showed altered circadian feeding behavior, sex-specific enhancement of insulin sensitivity, and elevated glucose uptake in skeletal muscle and brown adipose tissue. The findings indicate a role for ID2 as a regulator of glucose and lipid metabolism, and contribute to the understanding of the development of obesity and diabetes, particularly in shift work personnel. The study was published in PLoS One, 2013, 8, e73064, doi:10.1371/journal.pone.0073064.

Award Winners - NDIIF Best Imaging Publication Calendar Year 2014

April 17, 2015 – Notre Dame IN

The Notre Dame Integrated Imaging Facility (NDIIF) is pleased to announce two awards for best imaging publications for calendar year 2014.  Additional details available on College of Science News Webpage.

The Best Electron Microscopy Imaging Publication 2014 is awarded to Dr Rajesh Sahadevan, a post-doctoral research associate with Professor W. A. Philip in in the Department of Chemical and Biomolecular Engineering. Dr Sahadevan and coworkers published a paper entitled “Mixed Mosaic Membranes Prepared by Layer­by­Layer Assembly for Ionic Separations”. The project addressed the fabrication of mixed mosaic membranes (MMMs) with discrete positively charged and negatively charged domains. Due to this unique nanostructure, MMMs are capable of selectively separating dissolved ions from similarly-sized neutral solutes. Using the Magellan 400 scanning electron microscope (SEM) located in Stinson Remick Hall, micrographs were acquired that illustrated the feasibility of a layer-by-layer (LbL) technique to fabricate these unique membranes. Furthermore, SEM micrographs of the polymeric nanotubes helped control the dimensions (i.e., length, inner diameter and outer diameter) of these building blocks. The study was published in ACS Nano, 2014, 8, 12338–12345, DOI: 10.1021/nn504736w.    

 

The Best Biological Imaging Publication 2014 is awarded to Lisa Cole a graduate student with Professor R. K. Roeder in the Bioengineering Graduate Program, Department of Aerospace and Mechanical Engineering, and a collaborator with Professor T. Vargo-Gogola in the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine-South Bend. Cole and coworkers published a paper entitled “Contrast-Enhanced X-ray Detection of Breast Microcalcifications in a Murine Model Using Targeted Gold Nanoparticles”. Mammography is a clinical X-ray imaging tool for the early detection of breast cancer and the paper focused on microcalcifications of hydroxyapatite mineral within breast tissue and the most common abnormality detected by mammography. The detection of microcalcifications is limited by the sensitivity and specificity of mammography. The study investigated targeted delivery of bisphosphonate-functionalized gold nanoparticles for contrast-enhanced detection of microcalcifications using computed tomography. A combination of X-ray CT and TEM imaging data demonstrated for the first time that a targeted X-ray contrast agent could be used to improve the sensitivity and specificity of X-ray imaging for the early detection of breast microcalcifications. The study was published in ACS Nano, 2014, 8, 7486-7496, DOI: 10.1021/nn5027802.