The IVIS Lumina employs a super-cooled camera to provide extremely sensitive luminescence acquisitions. It also has basic fluorescence capabilities (8 excitation and 4 emission filters). Its primary use is for detection of bioluminescence in animal models of cancer or infection, in which transfected cells express luciferase enzymes that produce light.
Example images from the IVIS in the Notre Dame In Vivo Imaging Facility:
Subcutaneous prostate tumor expressing both luciferase for bioluminescence imaging (left panel), and mCherry for fluorescence imaging (right panel).